Faculty Profile - University of Houston
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Department of Biology and Biochemistry

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Faculty Profile

Brian KnollBrian Knoll

Associate Professor of Pharmacology
Pharmacological and Pharmaceutical Sciences Department

Office: 521 D SR2
Contact: bjknoll@mail.uh.edu - (713) 743-1299

Education: Ph.D. (Molecular Biology) University of Arizona

  • Lin R, Peng H, Nguyen LP, Dudekula NB, Shardonofsky F, Knoll BJ, Parra S, Bond RA. (2008). Changes in beta(2)-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulmonary Pharmacology and Therapy, 21(1):115-24.
  • Nguyen LP, Omoluabi O, Parra S, Frieske JM, Clement C, Ammar-Aouchiche Z, Ho SB, Ehre C, Kesimer M,Knoll BJ, Tuvim MJ, Dickey BF, Bond RA. (2008). Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. American Journal of Respiratory Cell and Molecular Biology, 38(3):256-62.
  • Moore RH, Millman EE, Godines V, Hanania NA, Tran TM, Peng H, Dickey BF, Knoll BJ, Clark RB. (2007). Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. American Journal of Respiratory Cell and Molecular Biology, 36(2):254-61.
  • Tran TM, Friedman J, Baameur F, Knoll BJ, Moore RH, Clark RB. (2007). Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Molecular Pharmacology, 71(1):47-60.
  • Awwad HO, Iyer V, Rosenfeld JL, Millman EE, Foster E, Moore RH, Knoll BJ. (2007). Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors. Experimental Cell Research, 313(12):2586-96.
  • Iyer V, Tran TM, Foster E, Dai W, Clark RB, Knoll BJ. (2006). Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. British Journal of Pharmacology, 147(3):249-59.
  • Vaughan DJ, Millman EE, Godines V, Friedman J, Tran TM, Dai W, Knoll BJ, Clark RB, Moore RH. (2006). Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. Journal of Biological Chemistry, 281(11):7684-92.
  • Millman EE, Rosenfeld JL, Vaughan DJ, Nguyen J, Dai W, Alpizar-Foster E, Clark RB, Knoll BJ, Moore RH. (2004). Endosome sorting of beta 2-adrenoceptors is GRK5 independent. British Journal of Pharmacology, 141(2):277-84.
  • Callaerts-Vegh Z, Evans KL, Dudekula N, Cuba D, Knoll BJ, Callaerts PF, Giles H, Shardonofsky FR, Bond RA. (2004). Effects of acute and chronic administration beta-adrenoceptor ligands on airway function in a murine model of asthma. Proceedings of the National Academy of Sciences of the United States of America, 101(14):4948-53.
  • Moore RH, Millman EE, Alpizar-Foster E, Dai W, Knoll BJ. (2004). Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. Journal of Cell Science, 117(Pt 15):3107-17.
  • Liu Q, Reubi JC, Wang Y, Knoll BJ, Schonbrunn A. (2003). In vivo phosphorylation of the somatostatin 2A receptor in human tumors. Journal of Clinical Endocrinology and Metabolism, 88(12):6073-9.
  • Clark RB, Knoll BJ. (2002). Measurement of receptor desensitization and internalization in intact cells. Methods in Enzymology, 343:506-29.
  • Rosenfeld JL, Knoll BJ, Moore RH. (2002). Regulation of G-protein-coupled receptor activity by rab GTPases. Receptors and Channels, 8(2):87-97.